RECENT AND UPCOMING PUBLICATIONS FROM OUR COLLABORATORS AND OUR TEAM:

AASLD2019 / Evaluation of a novel two‐photon microscopy‐based fibrosis phenotypic composite score and its correlation with serum neo-epitope collagen biomarkers in patients with NASH. Li Chen 1, Yi Luo 2, Faridoddin Mirshahi 3, Anthony Azzara 2, Arun Sanyal 3, Mathieu Petitjean 1 - PharmaNest, Princeton, NJ, USA; 2 Bristol-Myers Squibb Company, Princeton, NJ, USA 3-Virginia Commonwealth University, Richmond, VA, USA

AASLD2019 / Development of an Optimal Continuous Pediatric Fibrosis Score to Assess Severity and Progression of Fibrosis in Non-alcoholic Fatty Liver Disease (NAFLD). Elena Reynoso 1, Li Chen 2, Mathieu Petitjean 2, Cynthia Behling 3, Joel Lavine 1 - 1 Pediatric Gastroenterology, Hepatology & Nutrition, Columbia Vagelos College of Physicians and Surgeons, New York, NY 2 - PharmaNest Princeton, NJ - 3 University of California, San Diego, NAFLD Research Center, Division of Gastroenterology

AASLD2019 / Development of an Optimal Continuous Pediatric Fibrosis Score to Assess Severity and Progression of Fibrosis in Non-alcoholic Fatty Liver Disease (NAFLD). Elena Reynoso 1, Li Chen 2, Mathieu Petitjean 2, Cynthia Behling 3, Joel Lavine 1 -  1 Pediatric Gastroenterology, Hepatology & Nutrition, Columbia Vagelos College of Physicians and Surgeons, New York, NY 2 PharmaNest, Princeton, NJ 3 University of California, San Diego, NAFLD Research Center, Division of Gastroenterology

AASLD2019 / Automated Steatosis Morphometric Scores Benchmark the Pathology-Based Quantification of Steatosis in Pediatric NASH/NAFLD Populations. Zachary Pitkowsky 1, Li Chen 2, Elena Reynoso 1, Mathieu Petitjean 2, Cynthia Behling 3, Joel Lavine 1 - 1 Pediatric Gastroenterology, Hepatology & Nutrition, Columbia Vagelos College of Physicians and Surgeons, New York, NY 2 - PharmaNest Princeton, NJ - 3 University of California, San Diego, NAFLD Research Center, Division of Gastroenterology

Long-term obeticholic acid treatment is associated with improvements in collagen morphometry in patients with primary biliary cholangitis. Andreas E. Kremer, Christopher L. Bowlus, Pierre Bedossa, Albert Parés, Lisa M. Forman, Joost P.H. Drenth, Stephen Ryder, Luigi Terracciano, Yuying Jin, Alexander Liberman, Richard Pencek, Leigh MacConell, Paul J. Pockros

In press” Clinical Journal of Gastroenterology and Hepatolohy - Abstract here

Presented at EASL 2019 - Poster here

Morphometric collagen analysis discerns anti-fibrotic effects of INT-767 and OCA in NASH mouse models using second harmonic generation imaging. Li Chen, Mathieu Petitjean, Luciano Adorini, Jonathan Roth

Presented at EASL 2019 - Abstract SAT-342 - Poster here.

ASK1 Inhibition Reduces Progression of Liver Cirrhosis and Prevents Tumor Development in the BALS/c.Mdr2-/- Mouse Model of Biliary Fibrosis. G. Wei, P. An, K, Vaid, G. Budas, A. Mikels-Vigdal, M. Kuand, Y. Popov.

Presented at AASDL 2018. Poster here.

Quantitative Assessment of Liver Septal Fibrosis Severity Using Morphometric Analysis, Li Chen PhD., Anthony Azzara PhD., Mathieu Petitjean PhD., Presented at NASH-TAG 2018.

Poster here

Second Harmonic Generation Imaging Microscopy quantifies and characterizes fibrosis in the bowell wall of ulcerative colitis resection - A pilot study. Florian Reider et all. To be presented at DDW 2018 - June 2-5 2018

New Standards in Fibrosis Quantification: the Value of Label-free Second Harmonic Generation. Li Chen, Mathieu Petitjean at the Anti-fibrotic Drug Development Forum, November 13-14, 2017, Boston USA 

See slides from the podium presentation here

See poster here

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis (NASH). Jonathan D Roth, Michael Feigh, Sanne S Veidal, Louise K D Fensholdt, Kristoffer T G Rigbolt, Henrik H Hansen, Li C Chen, Mathieu Petitjean, Weslyn W Friley, Niels Vrang, Jacob Jelsing and Mark Young. World J Gastroenterol 2018 January 14; 24(2): 195-210

Paper here

Detailed Analysis of the Antifibrotic effect of INT-767, a dual FXR/TGR5 agonist in an obese mouse model of diet-induced and biopsy-confirmed NASH. Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth presented at AASLD 2017, October 20-23 , 2017.

See poster here (Presidential Award)

Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy. David W. Hammers, Coar C. Coker, Li Chen, Mathieu Petitjean, Elizabeth R.  Barton, H.Lee Sweeney presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

See poster picture here (poster PDF file to come)

Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS intestinal fibrosis model. Laura Johnson, Li.Chen, P. Higgings et all. Poster #2008 presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017.

Poster Here

Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models. M. Petitjean, J. Schwartz, Li Chen. Poster #3003 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

Poster Here

Quantification of Septa in Liver Fibrosis using Second Harmonic Generation Imaging. Li Chen, Mohammad Naser,  et all. Poster #1016 - presented at Keystone Injury, Inflammation and Fibrosis, March 26-30 2017

Poster Here